Metabolic Scaling Laws in Cancer (METLAWS).

Scaling laws describe how a metabolic or geometrical feature of a living organism changes with its size. As a classic example, Kleiber’s law explains how the metabolism of an organism grows as a function of its size. It is remarkable that metabolism changes at a slower pace than size does, the result of the existence of an underlying hierarchical vessel network. No one knows what the scaling law in tumors is and whether it could provide information on their aggressiveness. Positron emission tomography (PET) provides a way to assess metabolism macroscopically and could be used to investigate metabolic scaling laws in tumors.

Where is it being implemented?

The protocol has been approved and is running at Hospital General Universitario de Ciudad Real.

What data do we collect?

Retrospective PET data from patients from different types of tumors: glioblastoma, lung cancer, colorectal, breast cancer. Public data of head and neck cancers from the TCIA databases.

What are the expected benefits for patients?

If there is a scaling law, it could provide a reference to evaluate individual tumor aggressiveness and thus help in defining new METLAWS biomarkers.

When will the results be available?

Data collection has been completed. The tumors are being segmented and processed. We expect to have results sometime in 2019/2020.