Imaging Biomarkers in Glioblastoma
Glioblastoma is the most frequent and aggressive malignant primary brain tumor, with patient median survival of only 14 months from diagnosis. High resolution magnetic resonance imaging is routine for diagnosis, treatment planning, response evaluation and follow-up. We reconstruct the tumors in 3D and use mathematics to identify ‘hidden’ features (e.g. morphological or textural properties) related to patient prognosis and allowing to personalize treatments.
Publications
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A mesoscopic simulator to uncover heterogeneity and evolutionary dynamics in tumorsJ. Jiménez-Sánchez, A. Martínez-Rubio, A. Popov, J. Pérez-Beteta, Y. Azimzade, D. Molina-García, J. Belmonte-Beitia, G. F. Calvo, V. M. Pérez-GarcíaPLoS Computational Biology (2021, submitted, preprint available)
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Universal scaling laws rule explosive growth in human cancersVíctor M. Pérez-García, Gabriel F. Calvo, Jesús J. Bosque, Odelaisy León-Triana, Juan Jiménez, Julián Pérez-Beteta, J Belmonte-Beitia, M Valiente, L Zhu, P García-Gómez, P Sánchez-Gómez, E Hernández, R Hortigüela, Y. Azimzade, D Molina-García, A Martínez, A Acosta, A Ortiz de Mendivil, F Vallette, P Schucht, M Murek, M Pérez-Cano, D Albillo, AF Honguero, G. A. Jiménez, E Arana, AM García-VicenteNature Physics 16, 1232-1237 (2020)
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Tumor width on T1-weighted MRI images of glioblastoma as a prognostic biomarker: A mathematical modelJ. Pérez Beteta, J. Belmonte-Beitia, V.M. Pérez-GarcíaMathematical Modelling of Natural Phenomena 15, 10 (2020)
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18F-Fluorocholine PET/CT in the prediction of molecular subtypes and prognosis for gliomas.Ana M. Garcia Vicente, Julian Perez-Beteta, Mariano Amo-Salas, Francisco J. Pena Pardo, Maikal Villena, Hernan Sandoval, Manuela Mollejo, Rosa Barbella, Chistoph J. Klein, José M. Borras, Ángel M. Soriano, Víctor M. Pérez-GarcíaClinical Nuclear Medicine 44(10) e548-e558 (2019).
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Morphologic features on MR imaging classify multifocal glioblastomas in different prognostic groupsJ. Pérez-Beteta, D. Molina, M. Villena, M. Rodríguez, C. Velásquez, J. Martino, B. Meléndez, A.R. de Lope, R. Morcillo, J. Sepúlveda, A. Hernández, A. Ramos, J. Barcia, P. Lara, D. Albillo, A. Revert, E. Arana, V.M. Pérez-GarciaAmerican Journal of Neuro-radiology 40 (4) 634-640 (2019).
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Morphological MRI-based features provide pretreatment and post-surgery survival prediction in glioblastomaJ. Pérez-Beteta, D. Molina-García, A. Martínez-González, M. Amo, A. Henares-Molina, B. Luque, E. Arregui, M. Calvo, J.M.Borrás, J. Martino, C. Velasquez, B. Meléndez, A. R. de Lope, R. Moreno, J. A. Barcia, B. Asenjo, M. Benavides, I. Herruzo, P. C. Lara, R. Cabrera, D. Albillo, M. Navarro, L. A. Pérez-Romasanta, A. Revert, E. Arana, V. M. Pérez-GarcíaEuropean Radiology 29(4) 1968-1977 (2019)
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Prognostic models based on imaging findings in glioblastoma: Human versus MachineD. Molina-García, L. Vera, J. Pérez-Beteta, E. Arana, V. M. Pérez-GarcíaScientific Reports 9:5982 (2019)
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A three-dimensional computational analysis of magnetic resonance images characterizes the biological aggressiveness in malignant brain tumorsJ. Pérez-Beteta, A. Martínez-González, V. M. Pérez-GarcíaJournal of the Royal Society Interface 15, 20180503 (2018).
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Tumor Surface Regularity at MR Imaging Predicts Survival and Response to Surgery in Patients with GlioblastomaJ. Pérez-Beteta, D. Molina, A. Fernández, B. Luque, E. Arregui, M. Calvo, J. M. Borrás, A. Fernández-Romero, B. Luque, B. Meléndez, A.R. de Lope, R. Moreno, L. Iglesias, J.A. Barcia, J. Martino, C. Velasquez, B. Asenjo, M. Benavides, I. Herruzo, A. Revert, E. Arana, V. M. Pérez-GarcíaRadiology 288(1), 218-225 (2018)
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Glioblastoma: Does the pre-treatment geometry matter? A postcontrast T1 MRI-based studyJ. Pérez-Beteta, A. Martínez-González, D. Molina, M. Amo, B. Luque, E. Arregui, M. Calvo, J. M. Borrás, C. López, M. Claramonte, J. Barcia, L. Iglesias, J. Avecillas, D.Albillo, M. Navarro, J.M. Villanueva, J.C. Paniagua, J. Martino, C. Velasquez, B. Asenjo, M. Benavides, I. Herruzo, M.C. Delgado, A. Del Valle, A. Falkov, P. Schucht, E. Arana, L. Pérez-Romasanta, V. M.Pérez-GarcíaEuropean Radiology 27(3), 1096-1104 (2017)
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Novel geometrical imaging biomarkers predict survival and allow for patient selection for surgery in glioblastoma patientsJ. Pérez-Beteta, D. Molina, A. Martínez-González, E. Arregui, B. Asenjo, L. Iglesias, J. Martino, L. Pérez-Romasanta, E. Arana, V. M. Pérez-GarcíaNeuro-Oncology 19(3):iii80-iii80 (2017)
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Towards individualized survival prediction in glioblastoma patients using machine learning methodsL. Vera, J. Pérez-Beteta, D. Molina, J. M. Borrás, M. Benavides, J. A. Barcia, C. Velásquez, D. Albillo, P. Lara, V. M. Pérez-GarcíaNeuro-Oncology 19(3):iii84-iii84 (2017)
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Geometrical measures obtained from pretreatment postcontrast T1 weighted MRIs predict survival benefits from bevacizumab in glioblastoma patientsD. Molina, J. Pérez-Beteta, A. Martínez-González, J.M. Sepúlveda, S. Peralta, M. Gil-Gil, G. Reynes, A. Herrero, R. De Las Peñas, R. Luque, J. Capellades, C. Balaña, V.M. Pérez-GarciaPLoS One 11(8) e0161484 (2016).
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Tumour heterogeneity in glioblastoma assessed by MRI texture analysis: a potential marker of survival.D. Molina, J. Pérez-Beteta, B. Luque, E. Arregui, M. Calvo, J. M. Borrás, C. López, J. Martino, C. Velasquez, B. Asenjo, M. Benavides, I. Herruzo, A. Martínez-González, E. Arana. L. Pérez, V. M. Pérez-GarcíaBritish Journal on Radiology 89, 2016242 (2016)
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Bright solitary waves in malignant gliomas.V. M. Pérez-García, G. F. Calvo, J. Belmonte-Beitia, D. Diego, L. A. Pérez-RomasantaPhysical Review E 84, 021921 (2011)
Projects
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James S. Mc Donnell Foundation (USA) (2015 - 2016)
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James S. Mc. Donnell Foundation (USA) (2015 - 2018)
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James S. Mc. Donnell Foundation (USA) (2018 - 2021)
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Junta de Comunidades de Castilla-La Mancha (2018 - 2021)
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Ministerio de Ciencia e Innovación (Spain) (2020 - 2023)
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Ministerio de Economía y Competitividad (2016 - 2019)
Members
- Victor M. Pérez García
- Alicia Martínez González
- Luis Vera
- Carlos Velásquez
- Juan M. Sepúlveda
- Philippe Schucht
- Pilar Sánchez-Gómez
- Ana Ramos
- Luis Pérez Romasanta
- Julián Pérez Beteta
- David Molina García
- Bárbara Meléndez-Asensio
- Álvaro Martínez Rubio
- Belén Luque
- Juan Jiménez Sánchez
- Ismael Herruzo
- Aurelio Hernández-Laín
- Araceli Henares Molina
- Ana M. García
- Manuel Benavides
- Beatriz Asenjo Martínez
- Estanislao Arana
- José David Albillo Labarra