Biomarkers in diabetes and applications
Diabetes mellitus constitutes a major health problem and its clinical presentation and progression may vary considerably. Plasma glucose and glycated hemoglobin are routinely used for its diagnosis and monitoring. We use mathematical models to design novel biomarkers beyond the state of the art, e.g. based on the labile hemoglobin. They can offer additional information and/or provide alternative tools with some advantages for the diagnosis and monitoring of diabetes.
Labile Hemoglobin as a Glycemic Biomarker for Patient-Specific Monitoring of Diabetes: Mathematical Modelling ApproachO. León-Triana, G. F. Calvo, J. Belmonte-Beitia, M. Rosa Durán, J. Escribano-Serrano, A. Michan-Doña, V. M. Pérez-GarcíaJournal of the Royal Society Interface, 15(142), 20180224 (2018)