Blood flow and vasculature status in localised hyperthermia: A mathematical approach
2020 - Jesús J Bosque, Gabriel F Calvo, Víctor M Pérez-García, María Cruz Navarro
Royal Society Open Science (2020, submitted)
Abtract
Blood perfusion in tissues is known to have a major role in hyperthermia oncological treatments. In tissues with functional vessels, blood flow drives the heat away, thus cooling the heated regions, and provides oxygenation. The latter is of relevance when hyperthermia is used as coadjuvant with radiotherapy, since it is a major factor affecting radiotherapy outcome. Higher temperatures are linked to increases in blood perfusion that would enhance the degree to which the tumour is oxygenated and therefore improve the overall response in combination therapies. Since hyperthermia and radiotherapy are not usually administered simultaneously, a crucial question arises as how perfusion will be affected during and after hyperthermia. Here we propose a simple mathematical model for the evolution of temperature in tissues undergoing hyperthermia. We show that blood perfusion decreases steeply after the cessation of the heating source which would not explain by itself a possible improvement in oxygenation. Furthermore, we examine different scenarios of perfusion impairment mimicking effects of real tumour vasculature. Our simulations lead us to the conclusion that differences in vasculature between healthy and tumour tissues may have a great impact on temperature distribution and their peak values, thus affecting the outcome of cytotoxic treatments when performed in combination with hyperthermia.