Serum VEGF and VEGF-C values before surgery and after postoperative treatment in gastric cancer
2012 - P. Vallejo Campos, D. Padilla Valverde, R. Martín Martín, P. Sánchez Menéndez, T. Cubo Cintas, J.A. Bondia Navarro, J.A. Martín Fernández
Clinical & Translational Oncology. 15, 265-270 (2012)
authors IMACI
Abtract
Angiogenesis and lymphangiogenesis are essential processes for the formation of blood and lymphatic vessels that allow tumour growth and spread. The binding of VEGF and VEGF-C factors with their receptors (VEGFR2, VEGFR3) in endothelial cells triggers signals that regulate these processes. We compared preoperative serum VEGF and VEGF-C levels with samples obtained after completion of surgery and adjuvant treatment in patients with gastric cancer. In addition, we determined the prognostic value and relationship to survival of serum VEGF and VEGF-C levels.