Neutrophils, the most abundant cells in our innate immune system, appear to have many more functions in the body than previously thought. This has been confirmed in a recent publication in the prestigious journal Cell led by researchers from the National Center for Cardiovascular Research (CNIC) and coauthored by members of MOLAB. When neutrophils migrate and establish themselves in different tissues, they acquire distinctive traits that contribute not only to maintaining vital functions of the organs but also, under certain conditions, as co-drivers of several pathologies. At MOLAB we have contributed to the work published in Cell with the development of mathematical models that allowed quantifying the characteristic times of neutrophil functionality depending on the target organ. The finding opens up new therapeutic possibilities for the treatment of multiple diseases, such as cancer.
Link to the paper