Mathematical models are used in Science and Engineering to create conceptual frameworks in order to understand Nature and provide solutions to real-world problems. The TOG project (Therapy Optimization in Glioblastoma) aims to create a cooperative framework to gather together a broad range of human data of glioma patients and to develop efficient mathematical algorithms able to interpret this diverse information as a whole. The ultimate goal is to make knowledge-based decisions on which specific therapeutics, combinations and timings should be used for each glioblastoma (GBM) patient. Achieving this goal requires the integration of human clinical data coming from multimodal imaging, omics, immunohistochemical and molecular biology characterization of tumor cells, etc. Then, the conceptual frameworks provided by mathematical models, may allow us to get a “big picture” of the disease’s natural history and so understand and predict its response to therapies. Many hospitals have already joined the project including Hospital 12 de Octubre, Hospital de Ciudad Real, Hospital Marqués de Valdecilla, Hospital Regional de Málaga, Hospital Virgen de la Salud, Hospital de Albacete, MD Anderson Cancer Center (Madrid) and Hospital de Manises.
The last one to join the multidisciplinary team of coworkers has been the Erasme Hospital (Brussels, Belgium). An international recognized center, the different medical units of the hospital involved in the management of glioblastoma patients (radiology, pathology, neuro-surgery, medical oncology, radiation oncology, nuclear medicine) join our international effort to collect human data and design algorithms to optimize treatments for this devastating disease.