Seminar "Multiscale hybrid modeling of Glioblastoma Multiforme"
Sala de Juntas, Edificio Politécnico Campus de Ciudad Real, 11:00
Thursday December 04, 2014

Alfonso Caiazzo
Weierstrass Institute for Applied Analysis and Stochastics, Alemania
“Multiscale modeling of Glioblastoma Multiforme”
4 de Diciembre de 2014
11:00 Sala de Juntas, Edificio Politécnico
Campus de Ciudad Real, Universidad de Castilla-La Mancha



Palisades are multi-cellular circular structures that can be localized around occluded vascular vessels in glioblastomas. Palisade geometry suggests a formation process related to phenotypic changes in the tumour cell population, depending on the amount of nutrients available. In particular, palisade formation can be related to the ability of the tumour of becoming invasive.
Observation of palisades under microscopy is constrained to two dimensional layers as a consequence of the experimental setups. Advanced microscopy has been able to reproduce three dimensional images of particular tissue structures, 
however, up to our knowledge,  a three dimensional shape of palisades has not been reproduced yet. This is due to the difficult constraints that glioblastomas represent to be observed in-vivo. 
In this talk we present computational simulations of tumour growth and palisade formation, based on a multiscale coupling of an individual force based model for the evolution of tumor cells and a continuous PDE model for the oxygen diffusion from the blood vessels into the tissue, which can handle arbitrary vessel configurations. In particular, preliminary simulation results of tumour cell growth and migration in a bioreactor will be shown.