Glioblastomas (GBM) frequently appears as a solitary lesion at diagnosis but multiple lesions can occur. These tumors are termed multifocal or multicentric GBMs. These tumors account for 10-20% of all GBMs, with a poorer median survival of only 6-8 months from diagnosis.
A group of Molab researchers investigated the prognostic value of meaningful clinical and image-based parameters obtained from pretreatment volumetric magnetic resonance images. Also, prognostic models for MGBM patients using imaging biomarkers were developed. 97 patients harboring 239 tumors were included in the study. A multivariate model including with age, morphological properties and surgical treatment identified different groups with highly significant differences in terms of survival (c-index=0.85, median survival difference=10.55 months).
This work was based on the largest cohort of multifocal GBMs described the literature. The results open a new gate for treatment planning of MGBM, identifying a subgroup of patients with long survival being clearly benefited from extensive resections, a treatment usually denied for MGBMs.
"Morphologic features on MR imaging classify multifocal glioblastomas in different prognostic groups"J. Pérez-Beteta, D. Molina, M. Villena, M. Rodríguez, C. Velásquez, J. Martino, B. Meléndez, A.R. de Lope, R. Morcillo, J. Sepúlveda, A. Hernández, A. Ramos, J. Barcia, P. Lara, D. Albillo, A. Revert, E. Arana, V.M. Pérez-Garcia. American Journal of Neuro-radiology 40 (4) 634-640 (2019).