The Ministry of Science and Innovation has awarded the project "MAthematical models in Oncology" as part of the Spanish National research programme. In addition to the project, they have been awarded a complementary FPI fellowship for a PhD student to work in the group.
MMOncol represents a highly interdisciplinary research project comprising Mathematical Modelling, acting as the key conceptual hub, that links four areas of Oncology: Brain tumours, Leukaemias, Immunotherapy and Evolutionary Dynamics of Cancer. MMOncol involves applied mathematicans to address a wide range of challenging objectives supported by a sound methodology and data provided by five ongoing clinical studies from our medical collaborators. It represents the culmination of over ten years of activity in Biomathematics backed up by previous National and International research projects in the field, more than fifty scientific publications in first quartile journals, dozens of contributions to conferences and the organization of workshops and interdisciplinary meetings.
The project relies on the extensive use of differential equations, such as local and nonlocal reaction-diffusion and transport PDEs, compartment ODE-based models, together with stochastic discrete mesoscopic simulators. It also incorporates large data sets from large cohorts of cancer patients, together with data from experimental models (animal and cellular systems).
Equipped with such an armamentarium, the MMOncol objectives encompass improving the current therapeutics of malignant brain tumours (glioblastomas, low- grade gliomas and brain metastasis), acute lymphoblastic leukaemia or predicting the response to different state-of-the-art immunotherapy strategies. Besides, the project aims at identifying scaling laws in cancer by resorting to an evolutionary dynamics framework. Thus, MMOncol not only may contribute to provide novel quantitative tools with high translational potential that might be useful in the clinic, but it can also stimulate and attract a significant activity within the community of applied mathematicians by proposing relevant and interesting mathematical models amenable of new analytical techniques and theoretical studies.
The project will be developed by MOLAB researchers at University of Castilla-La Mancha and University of Cádiz (Spain). Under the leadership of Gabriel F. Calvo and Víctor M. Pérez-García (UCLM).