The second meeting of the collaborative group “Therapy optimization in glioblastoma: An integrative human-data based approach using mathematical models” was celebrated witht he participation of 40 researchers and clinicians from Spain, Switzerland, Poland, United Kingdom, Germany and United States of America. The participants belonged to various scientific fields including: Applied Mathematics, Clinical Oncology, Radiotherapy, Radiology, Pathology, Nuclear Medicine, Neuro-surgery and molecular and cellular biology.
The workshop goal was to complete a medical acquisition protocol to feed applied mathematicians with high-quality human data obtained in the framework of standard clinical practice of glioblastoma. This is the most lethal and frequent type of malignant brain cancer.
The clinical study will be implemented in the hospitals: 12 de Octubre de Madrid, Hospitales de Madrid, Complejo Universitario de Granada, Regional Universitario de Málaga, Universitario de Salamanca, Virgen de la Salud de Toledo y Universitario de Ciudad Real. This accounts for a large number of tumors per year and would allow to generate an unprecedented database including information from high-quality magnetic resonance images, genomics, positron emision tomography (PET) and clinical data. Using this information the applied mathematics teams of the project will try to find patterns of behavior of the disease and develop predictive models allowing to personalize the therapies. Preliminar results obtained at MôLAB on the basis of previous retrospective data are promising but more work is necessary.
The workshop has been funded by the collaborative activity award “Therapy optimization in glioblastoma: An integrative human-data based approach using mathematical models” awarded by the James S. Mc. Donnell Foundation to the University of Castilla-La Mancha. The mathematical department and the "Cátedra de innovación y desarrollo cooperativo y empresarial de la UCLM" have also contributed to the organization of the event.